ここでは原発巣推定に役立ちそうな抗体を参考までに挙げていますが、臓器(細胞)特異性の非常に高いものばかりとは限りません。また新生物においては形質発現が本来とは異なる場合もあります。絶対的な「マーカー」(ほとんどの場合"幻想"です)に期待するよりも複数の抗体の反応結果を総合的に解析する必要がある場合も多くあります。 |
■ 下垂体腺腫 ■ |
Human |
Adrenocorticotropic Hormone |
ACTH |
Adenocorticotropin |
Mouse |
56 |
P |
Human |
Follicular Stimulating Hormone |
FSH |
|
Mouse |
ZMFS1 |
P |
Human |
Growth hormone |
hGH |
|
Rabbit |
poly |
P |
Human |
Prolactin |
PRL |
|
Rabbit |
Poly |
P |
Human |
Thyroid Stimulating Hormone |
TSH |
|
Mouse |
ZMTS2 |
P |
■ 甲状腺・副甲状腺腫瘍 ■ |
Human |
Thyroglobulin |
ThG |
|
Rabbit |
Poly |
P |
Human |
Thyroid transcription factor-1 |
TTF-1 |
Thyroid nuclear factor 1,Homeobox protein Nkx-2.1 |
Mouse |
SPT24 |
P* |
Human |
Calcitonin |
Cal |
|
Rabbit |
Poly |
P |
Human |
Parathyroid Hormone |
PTH |
Parathormone |
Rabbit |
Poly |
P |
Human |
Peptide YY (PYY) |
PYY |
|
Rabbit |
Poly |
P |
■ 膵ラ氏島腫瘍 ■ |
Human |
Chromogranin A |
ChroA |
|
Rabbit |
Poly |
P |
Human |
Neural Cell Adhesion Molecule |
NCAM |
CD56,Leu-19,NKH-1 |
Mouse |
186 |
P* |
Human |
Neuron Specific Enolase |
NSE |
Enolaseγ-isozyme |
Rabbit |
NClVI-H14 |
P |
Human |
Protein Gene Product 9.5 |
PGP9.5 |
|
Mouse |
13C4 |
P |
Human |
Synaptphysin |
Synap |
|
Mouse |
27G12 |
P |
Human |
Gastrin |
Gas |
|
Rabbit |
Poly |
P |
Human |
Glucagon |
Glu |
|
Rabbit |
Poly |
P |
Human |
Insulin |
Ins |
|
Rabbit |
Poly |
P |
Human |
Pancreatic polypeptide |
PP |
PPP |
Rabbit |
Poly |
P |
Human |
Somatostatin |
Somat |
|
Rabbit |
Poly |
P |
Human |
Vasoactive Intestinal Polypeptide |
VIP |
|
Rabbit |
Poly |
P |
Human |
Substance-P |
SubP |
|
Rabbit |
Poly |
P |
■ 胎盤 ・ 性腺関連腫瘍 ■ |
Human |
Alpha-Fetoprotein |
AFP |
|
Rabbit |
Poly |
P |
Human |
CA-125 |
CA125 |
Ovarian cancer antigen |
Mouse |
OV185:1 |
P* |
Human |
CD30 |
CD30 |
Ki-1,Ber-H2 |
Mouse |
Ber-H2 |
P |
Human |
Carcinoembryonic Antigen |
CEA |
CD66e |
Rabbit |
Poly |
P |
Human |
c-kit |
cKit |
CD117,SCFR |
Rabbit |
Poly |
P |
Human |
Estradiol |
Est |
Es3 |
Rabbit |
Poly |
P |
Human |
Glypican-3 |
GPC3 |
MXR7, OCI5 |
Mouse |
1G12 |
P* |
Human |
Heat shock protein 70 |
HSP70 |
|
Mouse |
8B11 |
P* |
Human |
Human Chorionic Gonadotropin |
HCG |
|
Rabbit |
Poly |
P |
Human |
Human Chorionic Gonadotropin Beta subunit |
HCGβ |
|
Rabbit |
Poly |
P |
Human |
Human Placental Lactogen |
HPL |
|
Rabbit |
Poly |
P |
Human |
Luteinizing Hormone |
LH |
|
Mouse |
ZSL11 |
P |
Human |
p 57/Kip2 |
p57 |
Kip-2,→CDKN1C |
Rabbit |
EP2515Y |
P* |
Human |
Peptide YY(PYY) |
PYY |
|
Rabbit |
Poly |
P |
■ 胚細胞性 ■ |
|
Human |
Alkaline Phosphatase,Placental |
PALP |
ALP4 |
Rabbit |
Poly |
P |
Human |
D2-40 (Podoplanin) |
D2-40 |
Lymphatic endothelial marker |
Mouse |
D2-40 |
P* |
Human |
Glypican-3 |
GPC3 |
MXR7, OCI5 |
Mouse |
1G12 |
P* |
Human |
MAGE-1 |
MAGE1 |
|
Mouse |
6C1 |
P* |
■ 性腺間質性 ■ |
|
Human |
Estradiol |
Est |
Es3 |
Rabbit |
Poly |
P |
Human |
Inhibin, Alpha subunit |
aInh |
α-Inhibin |
Rabbit |
Poly |
P |
■ 前立腺癌 ■ |
Human |
α-Mehtylacyl-CoA Racemase |
AMACR |
AMACR, P504S |
Rabbit |
13H4 |
P* |
Human |
Androgen receptor |
AR |
|
Mouse |
AR441 |
P* |
Human |
Prostatic Acid Phosphatase |
PAP |
PSAP |
Mouse |
PASE/4LJ |
P |
Human |
Prostate Specific Antigen |
PSA |
|
Rabbit |
Poly |
P |
Human |
Prostate Specific Membrane Antigen |
PSMA |
PSM,FOLH1,GCP2,FGCP, mGCP (EC3.4.17.21) |
Mouse |
3E6 |
P* |
Human |
CD57 |
CD57 |
Leu-7,HNK-1 |
Mouse |
NK-1 |
P |
Human |
c-MET |
cMET |
HGF receptor |
Mouse |
8F11 |
P* |
Human |
Cytokeratin,High MW (34βE12) |
HMW-Ck |
Ck1/5/10/14 |
Mouse |
34βE12 |
P* |
Human |
Maspin |
Maspin |
Mammary specific serpin |
Mouse |
EAW24 |
P* |
■ 乳 癌 ■ |
Human |
Alpha-Smooth Muscle Actin |
SMA |
α-SMA |
Mouse |
1A4 |
P |
Human |
Calponin |
Calp |
|
Mouse |
CALP |
P* |
Human |
Estrogen receptor |
ER |
|
Mouse |
1D5 |
P* |
Human |
Estrogen receptor, beta |
ERβ |
|
Mouse |
EMR02 |
P* |
Human |
Mammaglobin |
MGb |
|
Rabbit |
31A5 |
P* |
Human |
Progesterone Receptor |
PgR |
|
Mouse |
PgR636 |
P* |
Human |
BRST-2 (GCDFP-15) |
BRST2 |
GCDFP-15 |
Mouse |
D6 |
P |
Human |
HER-2 |
HER-2 |
→c-erb B-2,neu |
Rabbit |
Poly |
P* |
Human |
Human Milk Fat Globule-1 |
HMFG1 |
|
Mouse |
EDM45 |
P* |
Human |
Maspin |
Maspin |
Mammary specific serpin |
Mouse |
EAW24 |
P* |
Human |
Muc-1 glycoprotein |
Muc1 |
|
Mouse |
Ma695 |
P* |
■ 肺 癌 ■ |
Human |
MOC-31 |
MOC31 |
Lung antigen, 40kD membrane protein2 |
Mouse |
MOC-31 |
P* |
■ 腺 癌 ■ |
|
Human |
CD15 |
CD15 |
X-hapten,Lewis X,LeX |
Mouse |
BY87 |
P |
Human |
Clara Cell 10kD protein |
CC10 |
|
Rabbit |
Poly |
P |
Human |
Surfactant apoprotein A |
SP-A |
Surfactant proteinA |
Mouse |
PE10 |
P |
Human |
Thyroid transcription factor-1 |
TTF-1 |
Thyroid nuclear factor 1,Homeobox protein Nkx-2.1 |
Mouse |
SPT24 |
P* |
■ 小細胞癌 ■ |
|
Human |
CD57 |
CD57 |
Leu-7,HNK-1 |
Mouse |
NK-1 |
P |
Human |
Neuron Specific Enolase |
NSE |
Enolaseγ-isozyme |
Mouse |
NclVI-H14 |
P |
Human |
Neural Cell Adhesion Molecule |
NCAM |
CD56,Leu-19,NKH-1 |
Mouse |
1B6 |
P* |
Human |
Protein Gene Product 9.5 |
PGP9.5 |
|
Mouse |
13C4 |
P |
Human |
Small Cell Lung Cancer |
SCLC |
SC-1 |
Mouse |
123C3 |
P |
Human |
Synaptophysin |
Synap |
|
Mouse |
27G12 |
P* |
■ 肝 癌 ■ |
Human |
Alpha-Fetoprotein |
AFP |
|
Rabbit |
Poly |
P |
Human |
Cytokeratin 7 |
Ck7 |
(MW=54kD) |
Mouse |
RN7 |
P* |
Human |
Cytokeratin 8 |
Ck8 |
(MW=52.5kD) |
Mouse |
TS1 |
P* |
Human |
Glypican-3 |
GPC3 |
MXR7, OCI5 |
Mouse |
1G12 |
P* |
Human |
Hepatocyte Specific Antigen |
HSA |
|
Mouse |
OCH1E5 |
P |
Human |
MAGE-1 |
MAGE1 |
|
Mouse |
6C1 |
P* |
■ 腎 癌 ■ |
Human |
Paired box protein-8 |
PAX-8 |
|
Mouse |
BC12 |
P* |
Human |
Wilms' tumor gene product |
WT-1 |
|
Mouse |
WT49 |
P* |
■ 尿路上皮癌 ■ |
Human |
Uroplakin III |
UPK3 |
|
Mouse |
SF-1 |
P |
■ 消 化 管 癌 ■ |
Human |
CA-19-9 |
CA19-9 |
Sialyl Lewis A,s-LeA |
Mouse |
C241:5:1:4 |
P |
Human |
Carcinoembryonic Antigen |
CEA |
CD66e |
Mouse |
12-140-10 |
P |
Human |
Caudal-type homeobox 2 |
CDX2 |
|
Mouse |
AMT28 |
P* |
Human |
CD10 |
|
→CALLA,commonALL, Neutral endopeptidase(NEP) |
Mouse |
56C6 |
P* |
Human |
DUPAN-2 |
DUPAN2 |
|
Mouse |
DU-PAN-2 |
P |
Human |
Epidermal growth factor receptor |
EGFR |
c-erbB1 |
Mouse |
EGFR113 |
P* |
Human |
Heat shock protein 70 |
HSP70 |
|
Mouse |
8B11 |
P* |
Human |
(human) Gastric mucin |
HGM |
|
Mouse |
45M1 |
P |
Human |
Muc-1 core peptide |
Muc1c |
|
Mouse |
Ma552 |
P* |
Human |
Muc-1 glycoprotein |
Muc1 |
|
Mouse |
Ma695 |
P* |
Human |
Muc-2 glycoprotein |
Muc2 |
Intestinal mucin |
Mouse |
Ccp58 |
P* |
Human |
Muc-5AC glycoprotein |
Muc5AC |
|
Mouse |
CLH2 |
P* |
Human |
Muc-6 glycoprotein |
Muc6 |
|
Mouse |
CLH5 |
P* |
Human |
Mucin |
HIK1083 |
|
Mouse |
M-GGMC-1 |
P* |
Human |
p53 protein |
p53 |
|
Mouse |
DO-7 |
P* |
Human |
Pepsinogen II |
PGII |
|
Sheep |
Poly |
P |
Human |
Villin |
|
|
Mouse |
CWWB1 |
P* |
■ GIST (GIMT) ■ |
|
Human |
Alpha-Smooth Muscle Actin |
SMA |
SMA |
Mouse |
1A4 |
P |
Human |
Caldesmon |
Cald |
|
Rabbit |
E89 |
P* |
Human |
CD34 |
CD34 |
Endothelial marker |
Mouse |
QBEND10 |
P |
Human |
c-kit |
CD117 |
CD117,SCFR |
Rabbit |
Poly |
P |
Human |
Desmin |
Des |
|
Mouse |
D33 |
P |
Human |
S-100 protein |
S100 |
|
Rabbit |
Poly |
P |
Human |
Vimentin |
Vim |
|
Mouse |
V9 |
P |